Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis

Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis

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Cholangiocarcinoma (CCA) is a malignancy arising from cholangiocytes.Currently, the treatment and prognosis for CCA are mostly poor.Recently, we have reported that coiled-coil domain containing 25 (CCDC25) protein level in the sera may be a diagnostic marker for CCA.Subsequently, we identified three binding proteins of CCDC25 and found that kallikrein-11 (KLK11) expression was highest among those binding proteins.

In this study, we investigated CCDC25 and KLK11 expression in CCA and adjacent normal tissues (n = 18) using immunohistochemistry.The results demonstrated that the expressions of ACNEDOTE FACE SCRUB CCDC25 and KLK11 in CCA tissues were both significantly higher than the adjacent tissues (p p = 0.001, respectively).Then, using GEPIA bioinformatics analysis, KLK11 mRNA was significantly overexpressed in CCA tumor tissues compared with normal tissues (p p = 0.

028, r = 0.593).An analysis for the interaction of KLK11 with CCDC25 and other proteins, using STRING version 11.0, revealed that CCDC25 and KLK11 Fuel Injectors correlated with metastasis-related proteins.

In addition, Kaplan-Meier survival curve analysis revealed that a high expression of KLK11 was associated with the poor prognosis of CCA.In conclusion, KLK11 is, as a binding protein for CCDC25, possibly involved in the metastatic process of CCA.KLK11 may be used as a prognostic marker for CCA.